Now showing items 1-6 of 6

    • Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix 

      Hua, Rui; Ni, Qingwen; Eliason, Travis D.; Han, Yan; Gu, Sumin; Nicolella, Daniel P.; Wang, Xiaodu; Jiang, Jean X. (Matrix Biology;Vol. 94, 9/28/2020)
      Recent in vitro evidence shows that glycosaminoglycans (GAGs) and proteoglycans (PGs) in bone matrix may functionally be involved in the tissue-level toughness of bone. In this study, we showed the effect of biglycan (Bgn), ...
    • Bioinspired design of hybrid composite materials 

      Maghsoudi-Ganjeh, Mohammad; Lin, Liqiang; Wang, Xiaodu; Zeng, Xiaowei (International Journal of Smart and Nano Materials;10(1), 11/24/2018)
      Mimicking the natural design motifs of structural biological materials is a promising approach to achieve a unique combination of strength and toughness for engineering materials. In this study, we proposed a 2D computational ...
    • Effect of water on nanomechanics of bone is different between tension and compression 

      Samuel, Jitin; Park, Jun-Sang; Almer, Jonathan; Wang, Xiaodu (Journal of the Mechanical Behavior of Biomedical Materials;57, 2016-04)
      Water, an important constituent in bone, resides in different compartments in bone matrix and may impose significant effects on its bulk mechanical properties. However, a clear understanding of the mechanistic role of water ...
    • An improved interfacial bonding model for material interface modeling 

      Lin, Liqiang; Wang, Xiaodu; Zeng, Xiaowei (Engineering Fracture Mechanics;169, 2017-01)
      An improved interfacial bonding model was proposed from potential function point of view to investigate interfacial interactions in polycrystalline materials. It characterizes both attractive and repulsive interfacial ...
    • Knockdown Indian Hedgehog (Ihh) does not delay Fibular Fracture Healing in genetic deleted Ihh mice and pharmaceutical inhibited Ihh Mice 

      Li, Shengchun; Xiang, Chuan; Wei, Xiaochun; Li, Hongbin; Li, Kai; Sun, Xiaojuan; Wang, Shaowei; Zhang, Min; Deng, Jin; Wang, Xiaodu; Li, Pengcui; Li, Ruifang; Zhang, Yanxiang; Wei, Lei (Scientific Reports;8, 7/9/2018)
      The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreERT2; Ihhfl/fl mice. Ihhfl/fl mice received Tamoxifen (TM) to delete Ihh. WT mice received ...
    • Nanomechanics and Ultrastructure of Bone: A Review 

      Maghsoudi-Ganjeh, Mohammad; Wang, Xiaodu; Zeng, Xiaowei (CMES-Computer Modeling in Engineering & Sciences;125(1), 11/1/2020)
      In this review, a brief presentation is first given to the hierarchical structure and mechanical behavior of bone. Then, the recent advancements in nanoscale characterization of bone ultrastructure and ingredients are ...