Now showing items 1-6 of 6
Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix
(Matrix Biology;Vol. 94, 9/28/2020)
Recent in vitro evidence shows that glycosaminoglycans (GAGs) and proteoglycans (PGs) in bone matrix may functionally be involved in the tissue-level toughness of bone. In this study, we showed the effect of biglycan (Bgn), ...
Knockdown Indian Hedgehog (Ihh) does not delay Fibular Fracture Healing in genetic deleted Ihh mice and pharmaceutical inhibited Ihh Mice
(Scientific Reports;8, 7/9/2018)
The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreERT2; Ihhfl/fl mice. Ihhfl/fl mice received Tamoxifen (TM) to delete Ihh. WT mice received ...
An improved interfacial bonding model for material interface modeling
(Engineering Fracture Mechanics;169, 2017-01)
An improved interfacial bonding model was proposed from potential function point of view to investigate interfacial interactions in polycrystalline materials. It characterizes both attractive and repulsive interfacial ...
Effect of water on nanomechanics of bone is different between tension and compression
(Journal of the Mechanical Behavior of Biomedical Materials;57, 2016-04)
Water, an important constituent in bone, resides in different compartments in bone matrix and may impose significant effects on its bulk mechanical properties. However, a clear understanding of the mechanistic role of water ...
Bioinspired design of hybrid composite materials
(International Journal of Smart and Nano Materials;10(1), 11/24/2018)
Mimicking the natural design motifs of structural biological materials is a promising approach to achieve a unique combination of strength and toughness for engineering materials. In this study, we proposed a 2D computational ...
Nanomechanics and Ultrastructure of Bone: A Review
(CMES-Computer Modeling in Engineering & Sciences;125(1), 11/1/2020)
In this review, a brief presentation is first given to the hierarchical structure and mechanical behavior of bone. Then, the recent advancements in nanoscale characterization of bone ultrastructure and ingredients are ...