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dc.contributor.authorLara, Humberto H.
dc.contributor.authorLopez-Ribot, Jose L.
dc.date.accessioned2021-04-19T15:22:53Z
dc.date.available2021-04-19T15:22:53Z
dc.date.issued9/25/2020
dc.identifierdoi: 10.3390/pathogens9100784
dc.identifier.citationPathogens 9 (10): 784 (2020)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/521
dc.description.abstractBoth bacterial and fungal organisms display the ability to form biofilms; however, mixed bacterial/fungal biofilms are particularly difficult to control and eradicate. The opportunistic microbial pathogens <i>Candida albicans</i> and <i>Staphylococcus aureus</i> are among the most frequent causative agents of healthcare-acquired infections, and are often co-isolated forming mixed biofilms, especially from contaminated catheters. These mixed species biofilms display a high level of antibiotic resistance; thus, these infections are challenging to treat resulting in excess morbidity and mortality. In the absence of effective conventional antibiotic treatments, nanotechnology-based approaches represent a promising alternative for the treatment of highly recalcitrant polymicrobial biofilm infections. Our group has previously reported on the activity of pure positively charged silver nanoparticles synthesized by a novel microwave technique against single-species biofilms of <i>C. albicans</i> and <i>S. aureus</i>. Here, we have expanded our observations to demonstrate that that silver nanoparticles display dose-dependent activity against dual-species <i>C. albicans</i>/<i>S. aureus</i> biofilms. Moreover, the same nanoparticles were used to functionalize catheter materials, leading to the effective inhibition of the mixed fungal/bacterial biofilms. Overall, our results indicate the potent activity of silver nanoparticles against these cross-kingdom biofilms. More studies are warranted to examine the ability of functionalized catheters in the prevention of catheter-related bloodstream infections.
dc.titleInhibition of Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus by Positively Charged Silver Nanoparticles and Functionalized Silicone Elastomers
dc.date.updated2021-04-19T15:22:53Z


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