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dc.contributor.authorAnderson, Jennifer L.
dc.contributor.authorNiedert, Elizabeth E.
dc.contributor.authorPatnaik, Sourav S.
dc.contributor.authorTang, Renxiang
dc.contributor.authorHolloway, Riley L.
dc.contributor.authorOsteguin, Vangelina
dc.contributor.authorFinol, Ender A.
dc.contributor.authorGoergen, Craig J.
dc.date.accessioned2021-04-19T15:25:26Z
dc.date.available2021-04-19T15:25:26Z
dc.date.issued1/9/2021
dc.identifierdoi: 10.3390/jcm10020219
dc.identifier.citationJournal of Clinical Medicine 10 (2): 219 (2021)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/540
dc.description.abstractAbdominal aortic aneurysms (AAAs) are a local dilation of the aorta and are associated with significant mortality due to rupture and treatment complications. There is a need for less invasive treatments to prevent aneurysm growth and rupture. In this study, we used two experimental murine models to evaluate the potential of pentagalloyl glucose (PGG), which is a polyphenolic tannin that binds to and crosslinks elastin and collagen, to preserve aortic compliance. Animals underwent surgical aortic injury and received 0.3% PGG or saline treatment on the adventitial surface of the infrarenal aorta. Seventeen mice underwent topical elastase injury, and 14 mice underwent topical calcium chloride injury. We collected high-frequency ultrasound images before surgery and at 3&ndash;4 timepoints after. There was no difference in the in vivo effective maximum diameter due to PGG treatment for either model. However, the CaCl<sub>2</sub> model had significantly higher Green&ndash;Lagrange circumferential cyclic strain in PGG-treated animals (<i>p</i> &lt; 0.05). While ex vivo pressure-inflation testing showed no difference between groups in either model, histology revealed reduced calcium deposits in the PGG treatment group with the CaCl<sub>2</sub> model. These findings highlight the continued need for improved understanding of PGG&rsquo;s effects on the extracellular matrix and suggest that PGG may reduce arterial calcium accumulation.
dc.titleAnimal Model Dependent Response to Pentagalloyl Glucose in Murine Abdominal Aortic Injury
dc.date.updated2021-04-19T15:25:26Z


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