Detection and genetic analysis of emerging influenza field strains

dc.contributor.advisorChambers, James P.
dc.contributor.authorDaum, Luke Thomas
dc.contributor.committeeMemberNiemyer, Debra
dc.contributor.committeeMemberWei, Tao
dc.contributor.committeeMemberGuentzel, Neal
dc.contributor.committeeMemberArulanandam, Bernard
dc.date.accessioned2024-02-09T20:48:43Z
dc.date.available2024-02-09T20:48:43Z
dc.date.issued2007
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractThe emergence and evolution of new and virulent strains of influenza virus poses a continuing threat to mankind. The devastation caused by the great pandemic of 1918 and the recent (1997-2008) outbreak of H5N1 avian influenza isolated in humans has elevated concerns of yet another human pandemic. This dissertation is a compilation of original, peer-reviewed publications describing: (1) development of rapid and robust influenza detection strategies and (2) elucidation of the immunodominant influenza surface glycoprotein amino acid residues, i.e., hemagglutinin and neuraminidase that define antigenicity and impart antigenic drift significantly affecting annually the use of therapeutic influenza vaccines. Development and utilization of these influenza diagnostic assays should prove to be of considerable value for 'point of care' screening during a future pandemic influenza outbreak. Equally important, the elucidation of key amino acid mutations from human influenza A and B field strains presenting in the 2004 and 2006 influenza seasons described in this dissertation have contributed directly to formulation changes in the globally distributed trivalent vaccine employed for protection against circulating influenza strains.
dc.description.departmentIntegrative Biology
dc.format.extent96 pages
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12588/3296
dc.languageen
dc.subjectdiagnostic detection
dc.subjectepidemiology
dc.subjectInfluenza
dc.subject.classificationEpidemiology
dc.subject.classificationMolecular biology
dc.subject.classificationVirology
dc.titleDetection and genetic analysis of emerging influenza field strains
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentIntegrative Biology
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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