Microbial co-infection alters phagocytic potential, cellular responses and intramacrophage bacterial replication

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dc.contributor.advisorArulanandam, Bernard
dc.contributor.authorTrivedi, Nikita Harikrishna
dc.contributor.committeeMemberGuentzel, Neal
dc.contributor.committeeMemberChambers, James
dc.date.accessioned2024-03-08T16:00:28Z
dc.date.available2024-03-08T16:00:28Z
dc.date.issued2013
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractHumans encounter multiple microorganisms every day. These microorganisms enter the host and interact with sentinel phagocytic cells such as macrophages. The macrophages engulf the microbes which get processed through the endocytic pathway. Many pathogens target macrophages and subvert the endocytic pathway and replicate inside these cells. It is more than likely that two different pathogens will be phagocytosed by the same macrophage. During such an encounter the host response generated by one pathogen will have its implications on the other pathogen present. In the current study, prior infection with Mycobacterium bovis BCG activates the macrophage to produce pro-inflammatory cytokines and nitric oxide, which helps it to control a subsequent Francisella tularensis LVS infection. The same effect is not seen in alternatively activated macrophages which do not produce nitric oxide. Overall, this study establishes a model to highlight different activation states of a macrophage and how different pathogens have the potential to modulate the host response.
dc.description.departmentIntegrative Biology
dc.format.extent44 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9781303392801
dc.identifier.urihttps://hdl.handle.net/20.500.12588/5977
dc.languageen
dc.subject.classificationImmunology
dc.subject.classificationMicrobiology
dc.titleMicrobial co-infection alters phagocytic potential, cellular responses and intramacrophage bacterial replication
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentIntegrative Biology
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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