Cannabidiol (CBD) for Dental Pain

dc.contributor.advisorMacpherson, Lindsey
dc.contributor.authorChrepa, Vanessa
dc.contributor.committeeMemberHargreaves, Kenneth
dc.contributor.committeeMemberWicha, Nicole
dc.contributor.committeeMemberRyba, Nicholas
dc.creator.orcidhttps://orcid.org/0000-0003-3136-378X
dc.date.accessioned2024-02-09T20:20:35Z
dc.date.available2024-02-09T20:20:35Z
dc.date.issued2023
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractObjective: To identify safer non-opioid analgesics for dental pain. Cannabidiol (CBD) is a non-psychoactive and non-addictive cannabinoid. CBD analgesic effectiveness for dental pain is largely unknown. This research proposed to identify CBD effectiveness, safety, and mechanism of action for treating dental pain using a translational in vivo model and a clinical trial. For the clinical trial, sixty-one patients with moderate-to-severe toothache were randomized into CBD 10mg/kg or 20mg/kg and Placebo. After a single oral dose, pain, bite force, and safety data were collected. Both CBD groups resulted in significant visual analog scale (VAS) pain reduction compared to their baseline and the Placebo, with a 73% maximum pain reduction. Bite force was significantly increased in CBD 20mg/kg compared to the Placebo Group. There were no psychoactive effects. The animal study utilized a behavioral mouse model of apical periodontitis-induced mechanical allodynia (MA) to assess CBD effectiveness, site of action, and transient receptor potential TRPV1 involvement. Mice received pulp exposure (AP) or sham surgery (Sham). Behavioral experiments were performed after 21 days with Von Frey filaments. AP mice that ingested CBD experienced a significant MA reduction compared to controls. Unlike intraoral injection, intrathecal and intracisternal CBD injection produced MA reduction in the AP (CBD) group, indicating a central site of action. Central TRPV1 inhibition blocked the CBD analgesic effect, suggesting TRPV1 involvement in CBD's MA reduction in the apical periodontitis model. Overall, CBD can be an effective analgesic for dental pain with a central site of action modulated through the TRPV1 channel.
dc.description.departmentNeuroscience, Developmental and Regenerative Biology
dc.format.extent71 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9798380126175
dc.identifier.urihttps://hdl.handle.net/20.500.12588/3234
dc.languageen
dc.subjectCannabidiol
dc.subjectClinical trial
dc.subjectDental pain
dc.subjectMechanical allodynia
dc.subjectToothache
dc.subject.classificationPharmacology
dc.subject.classificationPhysiology
dc.subject.classificationDentistry
dc.subject.classificationNeurosciences
dc.titleCannabidiol (CBD) for Dental Pain
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentNeuroscience, Developmental and Regenerative Biology
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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