In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates

Date
2018-04-26
Authors
Rezaei-Matehkolaei, Ali
Khodavaisy, Sadegh
Alshahni, Mohamad Mahdi
Tamura, Takashi
Satoh, Kazuo
Abastabar, Mahdi
Shokoohi, Gholam Reza
Ahmadi, Bahram
Kord, Mohammad
Taghipour, Simin
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract

The objective of this study was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 μg/ml), followed by lanoconazole (0.002 μg/ml), efinaconazole (0.007 μg/ml), terbinafine (0.011 μg/ml), itraconazole (0.095 μg/ml), and fluconazole (12.77 μg/ml). It appears that efinaconazole, lanoconazole, and luliconazole are promising candidates for the treatment of dermatophytosis due to T. interdigitale and T. rubrum.

Description
Keywords
dermatophytes, efinaconazole, in vitro susceptibility testing
Citation
Rezaei-Matehkolaei, A., Khodavaisy, S., Alshahni, M. M., Tamura, T., Satoh, K., Abastabar, M., . . . Badali, H. (2018). In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates. Antimicrobial Agents and Chemotherapy, 62(5). doi:10.1128/aac.02423-17
Department
Molecular Microbiology and Immunology