Eukaryotic gene prediction

Date
2011
Authors
Jleed, Hitham H.
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Abstract

Since the completion of the Human Genome Program in 21st century, there is an enormous amount of genomic and protein data available for use in public databases needed to be understood and analyzed. Gene prediction is one of the challenges in the analysis of newly sequenced genomes, and it is a basic step to an understanding of the genome. Thus, genomic DNA researches have rapidly increased to predict accurate genome structures of the DNA sequences, such as the promoter and coding regions. However, it is needed to find accurate and fast tools to analyze genomic sequences and annotate genes.

In this thesis, a new eukaryotic gene prediction will be introduced using digital signal processing tools that can improve the efficiency of promoter recognition and coding regions prediction. First, a new nucleotide orthogonal signal mapping scheme is introduced that maps the nucleotide sequences into discrete signals. Second, we develop a new algorithm that recognizes promoters in given eukaryotic genomic DNA sequences. Finally, we design a new algorithm that identifies the coding regions in eukaryotic DNA sequences, improving the coding prediction by heightening the protein coding region and smothering the non-coding region. We will compare the proposed system with commonly used techniques based on computer simulation. This system improves the accuracy of identifying the promoter and predicting the coding regions.

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Department
Electrical and Computer Engineering