Investigation of the Effects of Glucocortiocid Treatment on the CNS Proteome During EAE in the Absence of MIF

dc.contributor.advisorForsthuber, Thomas G.
dc.contributor.authorEscobar, Daniel Alberto
dc.contributor.committeeMemberGuentzel, Neal
dc.contributor.committeeMemberGupta, Rishein
dc.date.accessioned2024-02-09T20:49:26Z
dc.date.available2020-12-13
dc.date.available2024-02-09T20:49:26Z
dc.date.issued2018
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractMultiple sclerosis (MS) is a neuroinflammatory autoimmune disease characterized by damage to the myelin sheath surrounding neuronal axons. As there is currently no cure for multiple sclerosis, treatment methods aim to mediate the symptoms of the disease. The most common type of treatment for acute exacerbations of multiple sclerosis is glucocorticoid (GC) drugs. It is known that GC's induce the expression of the inflammatory cytokine macrophage migration inhibitory factor (MIF). The expression of this inflammatory cytokine reduces the efficacy of GC treatment. Previous work in our lab has shown that knock-out of MIF in conjunction with dexamethasone (Dex) treatment attenuates disease significantly more than Dex treatment in MIF sufficient mice. Our goal was to compare brain proteomes between MIF KO and WT EAE mice to better understand the mechanisms that underlie how MIF inhibition enhances the efficacy of GC treatment to attenuate disease. Using a high-throughput liquid chromatography mass spectrometry technique, several proteins were identified that exhibited differential protein expression between the MIF KO and WT mice at both 48 hours and 10 days post initiation of Dex treatment. We hypothesize that proteins expressed differentially between MIF KO mice and WT mice treated with Dex could provide novel therapeutic targets for the treatment of inflammatory autoimmune diseases.
dc.description.departmentIntegrative Biology
dc.format.extent29 pages
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12588/3354
dc.languageen
dc.subject.classificationImmunology
dc.titleInvestigation of the Effects of Glucocortiocid Treatment on the CNS Proteome During EAE in the Absence of MIF
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentIntegrative Biology
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Escobar_utsa_1283M_12707.pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format