In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species

Date

2016-12-27

Authors

Fakhim, Hamed
Emami, Saeed
Vaezi, Afsane
Hashemi, Seyedeh Mahdieh
Faeli, Leila
Diba, Kambiz
Dannaoui, Eric
Badali, Hamid

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.

Description

Keywords

in vitro susceptibility, triazole derivatives, Candida species

Citation

Fakhim, H., Emami, S., Vaezi, A., Hashemi, S. M., Faeli, L., Diba, K., Dannaoui, E., Badali, H. (2016). In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species. Antimicrobial Agents and Chemotherapy, 61(1). doi:10.1128/aac.01106-16

Department

Molecular Microbiology and Immunology