In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species

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dc.contributor.authorFakhim, Hamed
dc.contributor.authorEmami, Saeed
dc.contributor.authorVaezi, Afsane
dc.contributor.authorHashemi, Seyedeh Mahdieh
dc.contributor.authorFaeli, Leila
dc.contributor.authorDiba, Kambiz
dc.contributor.authorDannaoui, Eric
dc.contributor.authorBadali, Hamid
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-07-14T18:59:19Z
dc.date.available2023-07-14T18:59:19Z
dc.date.issued2016-12-27
dc.description.abstractThe in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.description.sponsorshipSchool of Medicine, Mazandaran University of Medical Sciences (Sari, Iran)en_US
dc.identifier.citationFakhim, H., Emami, S., Vaezi, A., Hashemi, S. M., Faeli, L., Diba, K., Dannaoui, E., Badali, H. (2016). In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species. Antimicrobial Agents and Chemotherapy, 61(1). doi:10.1128/aac.01106-16en_US
dc.identifier.issn1098-6596
dc.identifier.otherhttps://doi.org/10.1128/aac.01106-16
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1984
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy;Vol. 61, No. 1
dc.subjectin vitro susceptibilityen_US
dc.subjecttriazole derivativesen_US
dc.subjectCandida speciesen_US
dc.titleIn Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Speciesen_US
dc.typeArticleen_US

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