Antifungal therapy of Candida biofilms: Past, present and future

Date
2023-12
Authors
Ajetunmobi, Olabayo H.
Badali, Hamid
Romo, Jesus A.
Ramage, Gordon
Lopez-Ribot, Jose L.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract

Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections. There is a scarcity of antifungal agents, and their effectiveness, particularly against biofilms, is limited. Here we provide a historical perspective on antifungal agents and therapy of Candida biofilms. As we reflect upon the past, consider the present, and look towards the future of antifungal therapy of Candida biofilms, we believe that there are reasons to remain optimistic, and that the major challenges of Candida biofilm therapy can be conquered within a reasonable timeframe.

Description
Keywords
antifungal agents, Candida spp., biofilm
Citation
Ajetunmobi, O. H., Badali, H., Romo, J. A., Ramage, G., & Lopez-Ribot, J. L. (2023). Antifungal therapy of Candida biofilms: Past, present and future. Biofilm, 5, 100126. doi:https://doi.org/10.1016/j.bioflm.2023.100126
Department
Molecular Microbiology and Immunology