In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris

Date
2017-10-24
Authors
Fakhim, Hamed
Chowdhary, Anuradha
Prakash, Anupam
Vaezi, Afsane
Dannaoui, Eric
Meis, Jacques F.
Badali, Hamid
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract

We determined the in vitro interactions between echinocandins and azoles against 10 multidrug-resistant Candida auris strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.

Description
Keywords
in vitro interactions, azoles, echinocandins, Candida auris
Citation
Fakhim, H., Chowdhary, A., Prakash, A., Vaezi, A., Dannaoui, E., Meis, J. F., Badali, H. (2017). In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris. Antimicrobial Agents and Chemotherapy, 61(11). doi:10.1128/aac.01056-17
Department
Molecular Microbiology and Immunology