Computational Investigation of the Role of Mechanical Interactions on the Collective Cell Migration Behavior

dc.contributor.advisorZeng, Xiaowei
dc.contributor.authorBai, Jie
dc.contributor.committeeMemberZeng, Xiaowei
dc.contributor.committeeMemberYe, Jing Yong
dc.contributor.committeeMemberAbu-Lail, Nehal
dc.contributor.committeeMemberGao, Wei
dc.creator.orcidhttps://orcid.org/0000-0002-0712-022X
dc.date.accessioned2024-01-25T22:33:29Z
dc.date.available2023-08-25
dc.date.available2024-01-25T22:33:29Z
dc.date.issued2021
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractCell migration plays an essential role in many biological and physiological processes including morphogenesis, wound healing, and tumor metastases. Any abnormal migrations may result in severe defects or life-threatening scenarios, such as immunosuppression, autoimmune diseases, defective wound repair, or tumor formation and metastasis. To investigate the mechanisms underlying cell migration could lead to novel strategies and applications for controlling invasive tumor cells. Wound healing remains a challenging clinical problem and impaired wound healing affects 3~6 million people in the US. Epithelial wound healing is a complex process in which not only biochemical factors, but also physical factors play significant roles. Currently there are no advanced physics-based continuum models at cellular level which can capture the cell material property and deformation, cell-cell, cell-substrate interaction, etc. Therefore in this dissertation, our goal is to develop such continuum models to investigate the cell migration behavior. First (Essay Ⅰ), a continuum physics-based cell model was proposed using RKPM meshfree method to investigate the monocyte motility and intercellular adhesion during collective cell migration. Next (Essay Ⅱ), a two-dimensional finite element model was developed to study the cell migration behavior in a confluent epithelial monolayer, incorporating the interfacial interaction at each cell junction. Finally (Essay Ⅲ), a three-dimensional continuum computational model with finite element method was presented to investigate the mechanical factors that influence the wound healing process without cell division. Overall, the computational model developed in this study can be employed as a tool to unravel the mechanical principles behind the complex collective cell migration process. Results of this study might have the potential to improve effective medical management and optimize the treatment.
dc.description.departmentMechanical Engineering
dc.format.extent112 pages
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12588/2439
dc.languageen
dc.subjectcell migration
dc.subjectcomputational modeling
dc.subject.classificationMechanical engineering
dc.titleComputational Investigation of the Role of Mechanical Interactions on the Collective Cell Migration Behavior
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentMechanical Engineering
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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