Synaptic Inhibition of the External Globus Pallidus

Simple item page
dc.contributor.advisorWilson, Charles
dc.contributor.authorJones, James Alexander
dc.contributor.committeeMemberJaffe, David
dc.contributor.committeeMemberChan, Savio
dc.contributor.committeeMemberApicella, Alfonso
dc.contributor.committeeMemberSavelli, Francesco
dc.creator.orcidhttps://orcid.org/0000-0001-9836-466X
dc.date.accessioned2024-03-26T22:49:20Z
dc.date.available2024-03-26T22:49:20Z
dc.date.issued2023
dc.description.abstractThe external globus pallidus (GPe) is central to the basal ganglia, a large group of highly interconnected subcortical nuclei. Most synapses formed on and by GPe neurons are inhibitory. Most inhibitory synapses in the GPe arise from spiny projection neurons (SPNs) of the striatum, the input nucleus of the basal ganglia. The remaining inhibitory synapses arise locally from GPe neurons. To determine how GPe neurons integrate local and striatal synaptic inhibition, we isolated pallido-pallidal and striato-pallidal connections in slice preparations of the mouse GPe, performed whole cell voltage clamp recordings of the synaptic currents produced by the firing of SPNs and other GPe neurons, and performed perforated patch current clamp recordings of their effects on firing activity. The firing of GPe neurons produces synaptic inhibition of neurons in the substantia nigra pars reticulata (SNr), an output nucleus of the basal ganglia. To determine the fidelity of communication by the GPe, we performed perforated patch clamp recordings of GPe neurons in slice preparations, measured their entrainment by a wide range of input current frequencies, estimated the synaptic current this entrained firing would impose on SNr neurons, applied this current to SNr neurons, and measured the entrainment of SNr neurons by the original frequencies. Our findings indicate that the external globus pallidus is a network of inhibitory neurons that faithfully communicates a wide range of frequencies from the striatum to the substantia nigra.
dc.description.departmentNeuroscience
dc.format.extent1 electronic resource (178 pages)
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9798381181890
dc.identifier.urihttps://hdl.handle.net/20.500.12588/6247
dc.languageeng
dc.subjectAction potentials
dc.subjectBasal ganglia
dc.subjectExternal globus pallidus
dc.subjectStriatum
dc.subjectSubstantia nigra
dc.subjectSynaptic current
dc.subject.classificationNeurosciences
dc.subject.classificationPhysiology
dc.titleSynaptic Inhibition of the External Globus Pallidus
dc.typeThesis
dc.type.dcmiText
thesis.degree.departmentNeuroscience
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
v2.3_jamesjones_PhDdissertation_UTSA_2023.pdf
Size:
11.3 MB
Format:
Adobe Portable Document Format
Download

Collections

Electronic Theses and Dissertations - Open Access