Indifferent effect of nonsteroidal anti-inflammatory drugs (NSAIDs) combined with fluconazole against multidrug-resistant Candida auris

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dc.contributor.authorAhangarkani, Fatemeh
dc.contributor.authorKhodavaisy, Sadegh
dc.contributor.authorMahmoudi, Shahram
dc.contributor.authorShokohi, Tahereh
dc.contributor.authorRezai, Mohammad Sadegh
dc.contributor.authorFakhim, Hamed
dc.contributor.authorDannaoui, Eric
dc.contributor.authorFaraji, Saharnaz
dc.contributor.authorChowdhary, Anuradha
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorBadali, Hamid
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-06-20T17:02:00Z
dc.date.available2023-06-20T17:02:00Z
dc.date.issued2019-09
dc.description.abstractBackground and Purpose: Emergence and development of antifungal drug resistance in Candida species constitute a serious concern. Candida auris as an emerging multidrug-resistant fungus is the most important public health threat with high levels of mortality and morbidity. Almost all C. auris isolates are resistant to fluconazole, and there have been reports of elevated minimum inhibitory concentrations (MICs) to amphotericin B and echinocandins. To overcome the growing challenge of antifungal resistance, a valuable alternative option would be the use of drug combination. Materials and Methods: The present study evaluated the in vitro combination of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac and aspirin with fluconazole against fluconazole-resistant C. auris in comparison to other fluconazole-resistant Candida species, including C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, and C. krusei originating from patients with candidiasis. Results: The MIC ranges of fluconazole-ibuprofen and fluconazole-diclofenac decreased from 32-256 to 32-128 and 16-256 μg/ml, respectively and remained the same for fluconazole-aspirin against C. auris. However, the combination of fluconazole with ibuprofen resulted in a synergistic effect for 5 strains, including C. albicans (n=2), C. tropicalis (n=1), C. glabrata (n=1), and C. krusei (n=1), by decreasing the MIC of fluconazole by 2-3 log2 dilutions. Conclusion: Although the interaction of NSAIDs with fluconazole was not synergistic against fluconazole-resistant C. auris isolates, no antagonism was observed for any combinations. Therefore, combination with newer azole agents needs to be conducted.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.description.sponsorshipIran National Science Foundation; Mazandaran University of Medical Sciences, Sari, Iranen_US
dc.identifier.citationAhangarkani, F., Khodavaisy, S., Mahmoudi, S., Shokohi, T., Rezai, M. S., Fakhim, H., . . . Badali, H. (2019). Indifferent effect of nonsteroidal anti-inflammatory drugs (NSAIDs) combined with fluconazole against multidrug-resistant Candida auris. Current Medical Mycology, 5(3), 26-30. doi:10.18502/cmm.5.3.1743en_US
dc.identifier.issn2423-3420
dc.identifier.otherhttps://doi.org/10.18502/cmm.5.3.1743
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1902
dc.language.isoen_USen_US
dc.publisherMazandaran University of Medical Sciencesen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectantifungal drugsen_US
dc.subjectCandida aurisen_US
dc.subjectmultidrug-resistanten_US
dc.subjectNSAIDsen_US
dc.titleIndifferent effect of nonsteroidal anti-inflammatory drugs (NSAIDs) combined with fluconazole against multidrug-resistant Candida aurisen_US
dc.typeArticleen_US

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