Titon - torsional indirect traumatic optic neuropathy: a novel animal model

dc.contributor.advisorReilly, Matthew A.
dc.contributor.authorAsemota, Brooke
dc.contributor.committeeMemberSponsel, William E.
dc.contributor.committeeMemberRamasubramanian, Anand
dc.contributor.committeeMemberGlickman, Randolph D.
dc.date.accessioned2024-01-25T22:34:15Z
dc.date.available2024-01-25T22:34:15Z
dc.date.issued2014
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractThe purpose of this study was to establish a physiologically valid method for generating traumatic optic neuropathy in an experimental setting. 29 rats were subjected to varying levels of unilateral torsion generated by the TITON apparatus. Functional visual testing, in the form of the visual evoked potential (VEP), was performed before the torsion, immediately following the torsion, and one week after the torsion. All specimens received bilateral optic dissections for histological analysis. Threshold statistics were used to assess the data obtained during functional visual testing. The threshold values were determined to be 33.3° of rotation at an angular velocity of 2190°/s (p < 0.05), 39.4° at 1860°/s (p < 0.01), and 41.7° at 2190°/s (p < 0.001) for the induction of traumatic optic neuropathy using the TITON apparatus. Analysis of histology and functionality showed that the TITON mechanism was able to reliably reproduce traumatic optic neuropathy for rotational amplitudes and angular velocities at or above the statistically determined threshold.
dc.description.departmentBiomedical Engineering
dc.format.extent40 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9781303918865
dc.identifier.urihttps://hdl.handle.net/20.500.12588/2488
dc.languageen
dc.subjectindirect TON
dc.subjectocular trauma
dc.subjecttraumatic optic neuropathy
dc.subject.classificationBiomedical engineering
dc.subject.classificationBiomechanics
dc.subject.lcshEye -- Wounds and injuries -- Animal models
dc.subject.lcshNeuroophthalmology
dc.titleTiton - torsional indirect traumatic optic neuropathy: a novel animal model
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentBiomedical Engineering
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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