Synthesis and Biological Evaluation of Isoxazole Molecules Able To Induce Stem Cell Differentiation

dc.contributor.advisorFrantz, Doug E.
dc.contributor.authorAguilar, Hector R.
dc.contributor.committeeMemberKurtz, Donald
dc.contributor.committeeMemberNegrete, George
dc.contributor.committeeMemberZhao, John
dc.date.accessioned2024-01-25T19:32:07Z
dc.date.available2024-01-25T19:32:07Z
dc.date.issued2013
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractWithin the past few years there has been a growing interest in the ability to use small molecules to induce stem cell differentiation and promote the production of specific cell types such as neurons and cardiomyocytes. This area of research has great potential for treating diseases and traumas such as neurological disorders, limb amputations, spinal cord injuries, burns, heart disease and diabetes. Here we describe, the identification, synthetic optimization, and biological evaluation of 3,5-disubstituted isoxazoles able to induce stem cell differentiation towards a cardiogenic and neurogenic cell fate. This dissertation outlines an extensive structure activity relationship study of these 3,5-disubstituted isoxazoles in the attempt to increase their biological activity. We also demonstrate the application of these molecules as probes in delineating the biological processes involved in stem cell differentiation with particular interest in neurogenic tumorgenesis and myocardial repair.
dc.description.departmentChemistry
dc.format.extent261 pages
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12588/2354
dc.languageen
dc.subjectDifferentiation
dc.subjectIsoxazoles
dc.subjectMedicinal Chemistry
dc.subjectStem Cells
dc.subject.classificationChemistry
dc.subject.classificationBiology
dc.titleSynthesis and Biological Evaluation of Isoxazole Molecules Able To Induce Stem Cell Differentiation
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentChemistry
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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