Cocrystallization of thioamide and bipyridine-type molecules
| dc.contributor.advisor | Gorski, Waldemar | |
| dc.contributor.author | Ellis, Carol A. | |
| dc.contributor.committeeMember | Musie, Ghezai | |
| dc.contributor.committeeMember | Zhao, Cong-Gui | |
| dc.date.accessioned | 2024-02-09T20:49:00Z | |
| dc.date.available | 2024-02-09T20:49:00Z | |
| dc.date.issued | 2008 | |
| dc.description | This item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID. | |
| dc.description.abstract | Cocrystallization experiments conducted between thiocarbamide derivatives, (E)-O-alkyl N-aryl-thiocarbamide, of the general formula ROC(=S)N(H)R', for R = Me, Et and iPr and R' = Ph and C<sub>6</sub>H<sub>4</sub>NO<sub>2</sub>-4 containing an active pharmaceutical ingredient (API), i.e., -C(=S)-N(H)-, and bipyridine-type molecules, e.g., 4,4'-bipyridine, trans-1,2-bis(4-pyridyl)ethene and 1,2-bis(4-pyridyl)ethane, showed the formation of stable binary 2:1 cocrystals, e.g., {[ROC(=S)N(H)R']<sub>2</sub>(bipyridine-type molecule)}. Novel species were formed by grinding and solvent drop grinding methods, and characterized by X-ray powder diffraction methods. Five 2:1 cocrystals were isolated as single crystals by slow evaporation methods and subjected to full characterization by spectroscopic and X-ray crystallographic methods. This study shows that the eight-membered {...H-N-C=S}<sub>2</sub> homosynthon found in the parent thiocarbamides is readily disrupted in the presence of bipyridine-type molecules to enable the formation of the stable heterosynthon, {N...H-N}. | |
| dc.description.department | Chemistry | |
| dc.format.extent | 144 pages | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.isbn | 9780549917014 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12588/3324 | |
| dc.language | en | |
| dc.subject.classification | Pharmaceutical sciences | |
| dc.title | Cocrystallization of thioamide and bipyridine-type molecules | |
| dc.type | Thesis | |
| dc.type.dcmi | Text | |
| dcterms.accessRights | pq_closed | |
| thesis.degree.department | Chemistry | |
| thesis.degree.grantor | University of Texas at San Antonio | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science |
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