Microarray analysis of genes involved in drug addiction




Li, Qi

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Drug addiction is a disease of the brain with prominent hazardous effects leading to the collapse of health. It also has vicious influence to the social and economic stability. Long-term administration of drugs will likely lead to addiction, due to the activation and regulation of intracellular pathways in the brain reward system. It is of critical importance to develop a systematic understanding of the molecular mechanisms underlying the development of addiction leading to drug abuse. In this study, we performed secondary analysis of time course microarray expression profiles in response to six addictive drugs (cocaine, ethanol, morphine, methamphetamine, heroin, and nicotine) in the striatum of adult male C57BL/6J inbred mice (Piechota et al, 2010). Several statistical and bioinformatics methods, including two-way ANOVA and hierarchical clustering, were used to identify the genes that showed differential expression with the drug treatments over the time course. Gene ontology and pathway analysis were used to classify the functional categories of the drug-responsive genes and elucidate the cellular networks involving these genes or gene products.


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Integrative Biology