Distinct Subthreshold Signatures of Midbrain Dopamine Neurons Drive Firing Patterns During Noxious Events

dc.contributor.advisorWilson, Charles
dc.contributor.authorPerkins, Jessica M.
dc.contributor.committeeMemberMacpherson, Lindsey
dc.contributor.committeeMemberApicella, Alfonso
dc.contributor.committeeMemberWanat, Matthew
dc.contributor.committeeMemberRoeper, Jochen
dc.date.accessioned2024-02-12T19:30:16Z
dc.date.available2024-02-12T19:30:16Z
dc.date.issued2021
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractMidbrain dopamine neurons are strongly implicated in reward and aversion. Aversive stimuli are encoded by the firing pattern of dopamine neurons, which governs when dopamine is released at target regions. A response to an aversive stimulus is generated by integrating activity from multiple afferents, and changes in dopamine neuron firing activity are the result of dynamic changes in synaptic input. Using intracellular in vivo recordings, I was able to characterize the subthreshold signatures that elicit either an increase or decrease in dopamine firing activity. A spontaneous increase in dopamine neuron firing activity occurred via two distinct subthreshold mechanisms: 1) A large hyperpolarization followed by a rebound burst; and 2) a transient depolarization and plateau burst. Subthreshold responses evoked by a noxious foot shock were then characterized as either: 1) a large hyperpolarization during a pause in firing, 2) a depolarization during a phasic increase in firing, and 3) a large hyperpolarization followed by a rebound increase in firing activity. Determining the underlying biophysical mechanisms mediating changes in firing pattern provides insight into the afferents that elicit a response during a foot shock.
dc.description.departmentNeuroscience, Developmental and Regenerative Biology
dc.format.extent127 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9798759968931
dc.identifier.urihttps://hdl.handle.net/20.500.12588/4897
dc.languageen
dc.subjectDopamine
dc.subjectIn Vivo
dc.subjectMidbrain
dc.subjectNoxious
dc.subjectSubthreshold
dc.subjectVTA
dc.subject.classificationNeurosciences
dc.subject.classificationPhysiology
dc.subject.classificationPhysiological psychology
dc.titleDistinct Subthreshold Signatures of Midbrain Dopamine Neurons Drive Firing Patterns During Noxious Events
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentNeuroscience, Developmental and Regenerative Biology
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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