Synthesis, Characterization, and Investigation of Cobalt(II) Complexes as Mimics of Phosphoesterases

dc.contributor.advisorMusie, Ghezai
dc.contributor.authorTyus, Kendall Evan
dc.contributor.committeeMemberTonzetich, Zachary
dc.contributor.committeeMemberXu, Fang
dc.date.accessioned2024-03-08T16:00:36Z
dc.date.available2024-03-08T16:00:36Z
dc.date.issued2023
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractDrawing inspiration from biological systems, the development of a catalyst that can perform the hydrolysis of phosphoesters at a rate similar to that of phosphatases in nature has been pursued for decades. Although many catalysts containing various metals have been reported in literature, none have come close to replicating the rates of the natural enzymes, particularly in aqueous media. In an attempt to further expand the array of model catalyst, the ligands N-[2-carboxybenzomethyl]-N-[carboxymethyl]-β-alanine, H3camb, and N,N'-Bis[2-carboxybenzomethyl]-N,N'-Bis[carboxymethyl]-1,3-diaminopropan-2-ol, H5ccdp, have been employed in the synthesis and crystallization of three and full characterization of two novel cobalt(II) complexes. The complexes [Co(H2O)4Co2(camb)2(H2O)2]∙3H2O and (NMe4)2[Co2(ccdp)(µ-OAc)]·CH3CN have been studied for their activity towards catalyzing the hydrolysis of phosphoesters under Michaelis-Menten conditions in basic aqueous solutions. Lineweaver-Burke linearization was then used to determine the kinetic parameters Vmax, Km, and kcat for the two cobalt complexes.
dc.description.departmentChemistry
dc.format.extent77 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9798380126502
dc.identifier.urihttps://hdl.handle.net/20.500.12588/5994
dc.languageen
dc.subjectCobalt complexes
dc.subjectPhosphoesterases
dc.subject.classificationChemistry
dc.subject.classificationPolymer chemistry
dc.titleSynthesis, Characterization, and Investigation of Cobalt(II) Complexes as Mimics of Phosphoesterases
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentChemistry
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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