Whole Genome-Based Amplified Fragment Length Polymorphism Analysis Reveals Genetic Diversity in Candida africana

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dc.contributor.authorChowdhary, Anuradha
dc.contributor.authorHagen, Ferry
dc.contributor.authorSharma, Cheshta
dc.contributor.authorAl-Hatmi, Abdullah M. S.
dc.contributor.authorGiuffrè, Letterio
dc.contributor.authorGiosa, Domenico
dc.contributor.authorFan, Shangrong
dc.contributor.authorBadali, Hamid
dc.contributor.authorFelice, Maria Rosa
dc.contributor.authorde Hoog, Sybren
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorRomeo, Orazio
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-06-21T16:27:42Z
dc.date.available2023-06-21T16:27:42Z
dc.date.issued2017-04-03
dc.description.abstractThis study aimed at investigating the genetic diversity of a panel of Candida africana strains recovered from vaginal samples in different countries. All fungal strains were heterozygous at the mating-type-like locus and belonged to the genotype A of Candida albicans. Moreover, all examined C. africana strains lack N-acetylglucosamine assimilation and sequence analysis of the HXK1 gene showed a distinctive polymorphism that impair the utilization of this amino sugar in this yeast. Multi-locus sequencing of seven housekeeping genes revealed a substantial genetic homogeneity among the strains, except for the CaMPIb, SYA1 and VPS13 loci which contributed significantly to the classification of our set of C. africana strains into six existing diploid sequence types. Amplified fragment length polymorphism fingerprint analysis yielded greater genotypic heterogeneity among the C. africana strains. Overall the data reported here show that in C. africana genetic diversity occurs and the existence of this intriguing group of C. albicans strains with specific phenotypes associated could be useful for future comparative studies in order to better understand the genetics and evolution of this important human pathogen.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.identifier.citationChowdhary, A., Hagen, F., Sharma, C., Al-Hatmi, A. M. S., Giuffrè, L., Giosa, D., . . . Romeo, O. (2017). Whole Genome-Based Amplified Fragment Length Polymorphism Analysis Reveals Genetic Diversity in Candida africana. Frontiers in Microbiology, 8. doi:10.3389/fmicb.2017.00556en_US
dc.identifier.issn1664-302X
dc.identifier.otherhttps://doi.org/10.3389/fmicb.2017.00556
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1913
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectCandida africanaen_US
dc.subjectCandida albicansen_US
dc.subjectgenotypingen_US
dc.subjectmulti-locus sequence typingen_US
dc.subjectamplified fragment length polymorphismsen_US
dc.titleWhole Genome-Based Amplified Fragment Length Polymorphism Analysis Reveals Genetic Diversity in Candida africanaen_US
dc.typeArticleen_US

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