Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes

Date

2021-05-18

Authors

Badali, Hamid
Patterson, Hoja P.
Sanders, Carmita J.
Mermella, Barbara
Gibas, Connie F. C.
Ibrahim, Ashraf S.
Shaw, Karen J.
Wiederhold, Nathan P.

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

We evaluated the in vitro activity of manogepix against Fusarium oxysporum and Fusarium solani species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods. Manogepix demonstrated activity against both FOSC (MEC [minimum effective concentration] range, ≤0.015 to 0.03 μg/ml; MIC50 range, ≤0.015 to 0.125 μg/ml) and FSSC (MEC, ≤0.015 μg/ml; MIC50, ≤0.015 to 0.25 μg/ml). Amphotericin B was also active (MIC, 0.25 to 4 μg/ml), whereas the triazoles (MIC, 1 to >16 μg/ml) and micafungin (MEC, ≥8 μg/ml) had limited activity.

Description

Keywords

Fusarium oxysporum, Fusarium solani, manogepix, in vitro activity, minimum effective concentration, fosmanogepix, Fusarium, susceptibility

Citation

Badali, H., Patterson, H. P., Sanders, C. J., Mermella, B., Gibas, C. F. C., Ibrahim, A. S., . . . Wiederhold, N. P. (2021). Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes. Antimicrobial Agents and Chemotherapy, 65(6), 10.1128/aac.02343-02320. doi:10.1128/aac.02343-20

Department

Molecular Microbiology and Immunology