Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes

dc.contributor.authorBadali, Hamid
dc.contributor.authorPatterson, Hoja P.
dc.contributor.authorSanders, Carmita J.
dc.contributor.authorMermella, Barbara
dc.contributor.authorGibas, Connie F. C.
dc.contributor.authorIbrahim, Ashraf S.
dc.contributor.authorShaw, Karen J.
dc.contributor.authorWiederhold, Nathan P.
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-07-14T16:43:56Z
dc.date.available2023-07-14T16:43:56Z
dc.date.issued2021-05-18
dc.description.abstractWe evaluated the in vitro activity of manogepix against Fusarium oxysporum and Fusarium solani species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods. Manogepix demonstrated activity against both FOSC (MEC [minimum effective concentration] range, ≤0.015 to 0.03 μg/ml; MIC50 range, ≤0.015 to 0.125 μg/ml) and FSSC (MEC, ≤0.015 μg/ml; MIC50, ≤0.015 to 0.25 μg/ml). Amphotericin B was also active (MIC, 0.25 to 4 μg/ml), whereas the triazoles (MIC, 1 to >16 μg/ml) and micafungin (MEC, ≥8 μg/ml) had limited activity.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.identifier.citationBadali, H., Patterson, H. P., Sanders, C. J., Mermella, B., Gibas, C. F. C., Ibrahim, A. S., . . . Wiederhold, N. P. (2021). Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes. Antimicrobial Agents and Chemotherapy, 65(6), 10.1128/aac.02343-02320. doi:10.1128/aac.02343-20en_US
dc.identifier.issn1098-6596
dc.identifier.otherhttps://doi.org/10.1128/AAC.02343-20
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1978
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy;Vol. 65, No. 6
dc.subjectFusarium oxysporumen_US
dc.subjectFusarium solanien_US
dc.subjectmanogepixen_US
dc.subjectin vitro activityen_US
dc.subjectminimum effective concentrationen_US
dc.subjectfosmanogepixen_US
dc.subjectFusariumen_US
dc.subjectsusceptibilityen_US
dc.titleManogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexesen_US
dc.typeArticleen_US

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