Polymeric Device Characterization for Localized Targeted Drug Delivery Implant for Cervical Cancer

dc.contributor.advisorHood, R. Lyle
dc.contributor.authorElbjorn, Monica
dc.contributor.committeeMemberWan, Hung-Da
dc.contributor.committeeMemberWechsler, Marissa
dc.date.accessioned2024-02-09T20:48:58Z
dc.date.available2024-02-09T20:48:58Z
dc.date.issued2023
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractCervical cancer is a major global health problem, and despite technological advancements over the past four decades, the mortality rate for patients diagnosed with cervical cancer has remained unchanged. Currently, treatment options for cervical cancer include chemotherapy, radiation therapy, and surgical intervention. Personalized medical treatment aims to provide the right treatments to the right patients at the right time. Implantable drug delivery systems were developed to overcome problems associated with oral and injectable administration approaches such as patient adherence, bioavailability, and first-pass metabolism, among others. New combinations of biodegradable polymers have enabled numerous novel approaches to drug delivery. The proposed solution is the Multistage Polymer Delivery System (MPDS), which is a polymer device capable of minimally invasive placement and controlled drug administration over a span of several weeks. This study's objective was to show that the MPDS exhibits a linear biphasic controlled release profile, which would indicate potential as an effective treatment vehicle for cervical malignancies. An injection mold technique was developed to manufacture devices in batches. In vitro experiments demonstrated that the device’s geometry and surface area could be varied to achieve various drug release profiles. This study’s results encourage additional development of MPDS devices to treat cervical cancer, as well as other malignancies, such as lung, testicular, and ovarian cancers.
dc.description.departmentMechanical Engineering
dc.format.extent45 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9798379575526
dc.identifier.urihttps://hdl.handle.net/20.500.12588/3320
dc.languageen
dc.subjectCervical Cancer
dc.subjectPoly-lactic Acid
dc.subjectPolycaprolactone
dc.subjectPolymer Casting
dc.subjectPolymeric Drug Delivery
dc.subjectTargeted Drug Delivery System
dc.subject.classificationBiomedical engineering
dc.subject.classificationOncology
dc.subject.classificationBiochemistry
dc.subject.classificationPharmaceutical sciences
dc.titlePolymeric Device Characterization for Localized Targeted Drug Delivery Implant for Cervical Cancer
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentMechanical Engineering
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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