UTSA Student Works
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Browsing UTSA Student Works by Department "Biology"
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Item Alzheimer's Disease and Mini Brain Models (1st place winner)(2021-04-08) Acosta, Karina MeyerItem Arithmetic in the Bilingual Brain (3rd place winner)(2021-04-08) Cerda, VanessaItem Correlated Oxidative Stress and Mitochondrial Abnormalities in Aging are Discontinuous with Alzheimer’s Disease(Office of the Vice President for Research, 2018) Nguyen, Richard Q.; Bach, Stephan H.; Phelix, Clyde F.; Perry, GeorgeOxidative stress and mitochondrial damage precede Alzheimer’s disease (AD) hallmark pathologies, neurofibrillarytangles (NFT), and senile plaques.Mitochondria’s exact role in oxidation of pyruvate and NADH play a critical role in oxidative damage. We conducted this study to identify the relationship of oxidized RNA, 8--OHG biomarker, and mtDNA accumulation in AD and aging individuals. Abnormalities were examined by using densitometry of hippocampal pyramidal neurons: mtDNA accumulation as a marker of mitophagy and oxidative damage by 8-OHG. Among aging individuals, 8-OHG and mtDNA accumulation were highly correlated (R2=0.87,p=0.0007). While both 8-OHG and mtDNA were at higher levels in AD individuals, they were uncorrelated (R2=0.4418,p=0.07).In AD individuals, 8-OHG was inversely correlated with amyloid-β, while in aging, there was no significant correlation. These results suggest the discontinuity of similarities between aging and AD. These findings also indicate that the onset of AD is marked by a pleotrophic change in oxidative stress, one characterized by a change from mitochondria degeneration to amyloid-β independency.Item Geminivirus: Masters at Redirecting Host Cell Processes(2021-04-08) Williams, JacquelineItem Tail of the Striatum's Activity in Aversive Conditioning(UTSA Graduate School, 2024-04-02) Timmons, Sara; Bertero, Alice; Apicella, Alfonso J.Averse conditioning, also known as fear conditioning, is a form of associative learning in which a mouse learns to associate a conditioned stimulus (an auditory stimulus) with an unconditioned stimulus (foot shock).The striatum is the main input source of the basal ganglia, a collection of subcortical nuclei that mediate learning, memory and decision making, and its role in aversive conditioning remains to be fully elucidated. Here, we seek to better understand the involvement of the tail of the striatum (TS) in auditory aversive conditioning by utilizing c-FOS immunohistochemistry to examine changes in its expression as a measure of neuronal activity following conditioning. This study contributes to a deeper understanding of the neural circuitry underlying aversive and learning behaviors.