Show brief item record

dc.contributor.authorDallmann, Alexandria
dc.contributor.authorNarayan, Lauren
dc.contributor.authorRocha, Sarah
dc.contributor.authorZamarripa, Claudia
dc.contributor.authorGlover, Johnny III
dc.contributor.authorVallor, Ana
dc.contributor.authorCarvalho, Paulo
dc.date.accessioned2020-06-19T22:56:18Z
dc.date.available2020-06-19T22:56:18Z
dc.date.issued2019
dc.identifier.issn2470-3958
dc.identifier.urihttps://hdl.handle.net/20.500.12588/108
dc.description.abstractObjective: Synthesize b-ketonitriles as intermediates towards an effective drug to counteract the parasitic tropical disease leishmaniasis. Introduction: Diaminopyrimidines have been used as drugs against parasitic diseases like malaria, and less notably against leishmaniasis. Increased resistance, decreased efficacy, and severe side effects have been observed in the current treatment regimen highlighting the need for new drugs against those diseases. Methods: Six esters reacted with four different nitriles in the presence of potassium tert-butoxide using tetrahydrofuran as solvent to form b-ketonitriles. Results: Twenty-four b-ketonitriles were synthesized using a microwave reactor, with yields varying from 30 to 72%. Conclusion: Microwave conditions are appropriate for the synthesis of b-ketonitriles. Yields were variable, with starting materials containing amino groups resulting in lower yields of solid compounds of difficult purification.en_US
dc.publisherOffice of the Vice President for Researchen_US
dc.relation.ispartofseriesThe UTSA Journal of Undergraduate Research and Scholarly Work;Volume 5
dc.titleKetonitriles as Intermediates for the Synthesis of Antiparasitic Drugsen_US
dc.typePosteren_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show brief item record