Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates

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dc.contributor.authorBadiee, Parisa
dc.contributor.authorBadali, Hamid
dc.contributor.authorBoekhout, Teun
dc.contributor.authorDiba, Kambiz
dc.contributor.authorMoghadam, Abdolkarim Ghadimi
dc.contributor.authorHossaini Nasab, Ali
dc.contributor.authorJafarian, Hadis
dc.contributor.authorMohammadi, Rasoul
dc.contributor.authorMirhendi, Hossein
dc.contributor.authorNajafzadeh, Mohammad Javad
dc.contributor.authorShamsizadeh, Ahmad
dc.contributor.authorSoltani, Jafar
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-06-20T15:42:29Z
dc.date.available2023-06-20T15:42:29Z
dc.date.issued2017-11-21
dc.description.abstractBackground: Antifungal susceptibility testing is a subject of interest in the field of medical mycology. The aim of the present study were the distributions and antifungal susceptibility patterns of various Candida species isolated from colonized and infected immunocompromised patients admitted to ten university hospitals in Iran. Methods: In totally, 846 Candida species were isolated from more than 4000 clinical samples and identified by the API 20 C AUX system. Antifungal susceptibility testing was performed by broth microdilution method according to CLSI. Results: The most frequent Candida species isolated from all patients was Candida albicans (510/846). The epidemiological cutoff value and percentage of wild-type species for amphotericin B and fluconazole in Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei were 0.5 μg/ml (95%) and 4 μg/ml (96%); 1 μg/ml (95%) and 8 μg/ml (95%); 0.5 μg/ml (99%) and 19 μg/ml (98%); and 4 μg/ml (95%) and 64 μg/ml (95%), respectively. The MIC90 and epidemiological cutoff values to posaconazole in Candida krusei were 0.5 μg/ml. There were significant differences between infecting and colonizing isolates of Candida tropicalis in MIC 90 values of amphotericin B, and isolates of Candida glabrata in values of amphotericin B, caspofungin, and voriconazole (P < 0.05). Conclusions: Our findings suggest that the susceptibility patterns of Candida species (colonizing and infecting isolates) in immunocompromised patients are not the same and acquired resistance was seen in some species.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.identifier.citationBadiee, P., Badali, H., Boekhout, T., Diba, K., Moghadam, A. G., Hossaini Nasab, A., . . . Soltani, J. (2017). Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates. BMC Infectious Diseases, 17(1), 727. doi:10.1186/s12879-017-2825-7en_US
dc.identifier.issn1471-2334
dc.identifier.otherhttps://doi.org/10.1186/s12879-017-2825-7
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1899
dc.language.isoen_USen_US
dc.publisherBMCen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectcolonizing Candidaen_US
dc.subjectCandida infected patientsen_US
dc.subjectCandida wild-typeen_US
dc.subjectCandida susceptibility testingen_US
dc.subjectCandida albicansen_US
dc.titleAntifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolatesen_US
dc.typeArticleen_US

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