Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions

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dc.contributor.authorAcosta, Francisca M.
dc.contributor.authorStojkova, Katerina
dc.contributor.authorZhang, Jingruo
dc.contributor.authorGarcia Huitron, Eric Ivan
dc.contributor.authorJiang, Jean X.
dc.contributor.authorRathbone, Christopher R.
dc.contributor.authorBrey, Eric M.
dc.creator.orcidhttps://orcid.org/0000-0001-8766-7390en_US
dc.date.accessioned2023-05-10T18:07:30Z
dc.date.available2023-05-10T18:07:30Z
dc.date.issued2022-06-24
dc.description.abstractEngineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may contain cells capable of differentiation into thermogenic, or beige, adipocytes. In this study, culture conditions were investigated to engineer three-dimensional, vascularized functional beige adipose tissue using microvascular fragments isolated from both healthy animals and a model of type II diabetes (T2D). Vascularized beige adipose tissues were engineered and exhibited increased expression of beige adipose markers, enhanced function, and improved cellular respiration. While microvascular fragments isolated from both lean and diabetic models were able to generate functional tissues, differences were observed in regard to vessel assembly and tissue function. This study introduces an approach that could be employed to engineer vascularized beige adipose tissues from a single, potentially autologous source of cells.en_US
dc.description.departmentBiomedical Engineering and Chemical Engineeringen_US
dc.description.sponsorshipNational Institutes of Health; Veterans Administration; University of Texas System Science and Technology Acquisition and Retention Program; University of Texas Department of Biomedical Engineering and Chemical Engineeringen_US
dc.identifier.citationAcosta, F. M., Stojkova, K., Zhang, J., Garcia Huitron, E. I., Jiang, J. X., Rathbone, C. R., & Brey, E. M. (2022). Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions. Journal of Tissue Engineering, 13, 20417314221109337. doi:10.1177/20417314221109337en_US
dc.identifier.issn2041-7314
dc.identifier.otherhttps://doi.org/10.1177/20417314221109337
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1830
dc.language.isoen_USen_US
dc.publisherSAGE Publicationsen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectbeige adipose tissueen_US
dc.subjectfaten_US
dc.subjectmicrovascular fragmentsen_US
dc.subjecttissue engineeringen_US
dc.subjecttype 2 diabetesen_US
dc.titleEngineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditionsen_US
dc.typeArticleen_US

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