Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits

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dc.contributor.authorNguyen, Huynh Nga
dc.contributor.authorUllevig, Sarah L.
dc.contributor.authorShort, John D.
dc.contributor.authorWang, Luxi
dc.contributor.authorAhn, Yong Joo
dc.contributor.authorAsmis, Reto
dc.date.accessioned2021-08-26T13:26:58Z
dc.date.available2021-08-26T13:26:58Z
dc.date.issued2021-07-21
dc.date.updated2021-08-26T13:27:00Z
dc.description.abstractUrsolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA’s main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid.
dc.description.departmentNutrition and Dietetics
dc.identifierdoi: 10.3390/antiox10081161
dc.identifier.citationAntioxidants 10 (8): 1161 (2021)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/670
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbotanicals
dc.subjectnutraceutical
dc.subjectantioxidants
dc.subjectinflammation
dc.subjectmetabolic diseases
dc.subjectatherosclerosis
dc.subjectcancer
dc.titleUrsolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
dc.typeArticleen_US

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