Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species
Date
2018-04-26
Authors
Abastabar, Mahdi
Moghaddam, Mohammad Vafaei
de Hoog, G. Sybren
Haghani, Iman
Aghili, Seyed Reza
Shokohi, Tahereh
Hedayati, Mohammad Taghi
Ghazvini, Roshanak Daie
Kachuei, Reza
Rezaei-Matehkolaei, Ali
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
A collection of clinical (n = 47) and environmental (n = 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.
Description
Keywords
Fusarium species, intrinsic resistance, luliconazole, lanoconazole
Citation
Abastabar, M., Al-Hatmi, A. M. S., Moghaddam, M. V., de Hoog, G. S., Haghani, I., Aghili, S. R., ... Badali, H. (2018). Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species. Antimicrobial Agents and Chemotherapy, 62(5). doi:10.1128/aac.00009-18
Department
Molecular Microbiology and Immunology