Switching to a Standard Chow Diet at Weaning Improves the Effects of Maternal and Postnatal High-Fat and High-Sucrose Diet on Cardiometabolic Health in Adult Male Mouse Offspring

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dc.contributor.authorChiƱas Merlin, Andrea
dc.contributor.authorGonzalez, Kassandra
dc.contributor.authorMockler, Sarah
dc.contributor.authorPerez, Yessenia
dc.contributor.authorJia, U-Ter Aondo
dc.contributor.authorChicco, Adam J.
dc.contributor.authorUllevig, Sarah L.
dc.contributor.authorChung, Eunhee
dc.date.accessioned2022-06-23T12:11:50Z
dc.date.available2022-06-23T12:11:50Z
dc.date.issued2022-06-18
dc.date.updated2022-06-23T12:11:52Z
dc.description.abstractCardiac mitochondrial dysfunction contributes to obesity-associated heart disease. Maternal and postnatal diet plays an important role in cardiac function, yet the impacts of a mismatch between prenatal and postweaning diet on cardiometabolic function are not well understood. We tested the hypothesis that switching to a standard chow diet after weaning would attenuate systemic metabolic disorders and cardiac and mitochondrial dysfunction associated with maternal and postnatal high-fat/high-sucrose (HFHS) diet in mice. Six-month-old male CD1 offspring from dams fed a HFHS diet and weaned to the same HFHS diet (HH) or switched to a standard chow diet (HC) were compared to offspring from dams fed a low-fat/low-sucrose diet and maintained on the same diet (LL). HC did not decrease body weight (BW) but normalized glucose tolerance, plasma cholesterol, LDL, and insulin levels compared to the HH. Systolic function indicated by the percent fractional shortening was not altered by diet. In freshly isolated cardiac mitochondria, maximal oxidative phosphorylation-linked respiratory capacity and coupling efficiency were significantly higher in the HC in the presence of fatty acid substrate compared to LL and HH, with modification of genes associated with metabolism and mitochondrial function. Switching to a standard chow diet at weaning can attenuate the deleterious effects of long-term HFHS in adult male mouse offspring.
dc.description.departmentKinesiology
dc.identifierdoi: 10.3390/metabo12060563
dc.identifier.citationMetabolites 12 (6): 563 (2022)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/876
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdiabetes
dc.subjectobesity
dc.subjectmale mouse offspring
dc.subjectglucose and insulin tolerance tests
dc.subjectsystolic function
dc.titleSwitching to a Standard Chow Diet at Weaning Improves the Effects of Maternal and Postnatal High-Fat and High-Sucrose Diet on Cardiometabolic Health in Adult Male Mouse Offspring
dc.typeArticleen_US

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