Dietary Supplementation with 23-Hydroxy Ursolic Acid Reduces the Severity and Incidence of Acute Experimental Autoimmune Encephalomyelitis (EAE) in a Murine Model of Multiple Sclerosis
| dc.contributor.author | Asmis, Reto | |
| dc.contributor.author | Medrano, Megan T. | |
| dc.contributor.author | Chase Huizar, Carol | |
| dc.contributor.author | Griffith, Wendell P. | |
| dc.contributor.author | Forsthuber, Thomas G. | |
| dc.date.accessioned | 2024-06-28T15:08:35Z | |
| dc.date.available | 2024-06-28T15:08:35Z | |
| dc.date.issued | 2024-01-25 | |
| dc.date.updated | 2024-06-28T15:08:35Z | |
| dc.description.abstract | 23-Hydroxy ursolic acid (23-OH UA) is a potent atheroprotective and anti-obesogenic phytochemical, with anti-inflammatory and inflammation-resolving properties. In this study, we examined whether dietary 23-OH UA protects mice against the acute onset and progression of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Female C57BL/6 mice were fed either a defined low-calorie maintenance diet (MD) or an MD supplemented with 0.2% wgt/wgt 23-OH UA for 5 weeks prior to actively inducing EAE and during the 30 days post-immunization. We observed no difference in the onset of EAE between the groups of mice, but ataxia and EAE disease severity were suppressed by 52% and 48%, respectively, and disease incidence was reduced by over 49% in mice that received 23-OH UA in their diet. Furthermore, disease-associated weight loss was strikingly ameliorated in 23-OH UA-fed mice. ELISPOT analysis showed no significant differences in frequencies of T cells producing IL-17 or IFN-γ between 23-OH UA-fed mice and control mice, suggesting that 23-OH UA does not appear to regulate peripheral T cell responses. In summary, our findings in EAE mice strongly suggest that dietary 23-OH UA may represent an effective oral adjunct therapy for the prevention and treatment of relapsing–remitting MS. | |
| dc.identifier | doi: 10.3390/nu16030348 | |
| dc.identifier.citation | Nutrients 16 (3): 348 (2024) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12588/6458 | |
| dc.title | Dietary Supplementation with 23-Hydroxy Ursolic Acid Reduces the Severity and Incidence of Acute Experimental Autoimmune Encephalomyelitis (EAE) in a Murine Model of Multiple Sclerosis |