Evaluating the Performance of a Nonelectronic, Versatile Oxygenating Perfusion System across Viscosities Representative of Clinical Perfusion Solutions Used for Organ Preservation

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dc.contributor.authorGonzalez, Jose M.
dc.contributor.authorVillarreal, Carorina
dc.contributor.authorFasci, Anjelyka
dc.contributor.authorDi Rocco, David
dc.contributor.authorSalazar, Sophia
dc.contributor.authorKhalil, Anis
dc.contributor.authorWearden, Brandt
dc.contributor.authorOseghale, Jessica
dc.contributor.authorGarcia, Mariana
dc.contributor.authorPortillo, Daniel J.
dc.contributor.authorHood, R. Lyle
dc.date.accessioned2023-01-20T14:22:59Z
dc.date.available2023-01-20T14:22:59Z
dc.date.issued2022-12-20
dc.date.updated2023-01-20T14:23:00Z
dc.description.abstractIntroduction: On the United States' Organ Transplantation Waitlist, approximately 17 people die each day waiting for an organ. The situation continues to deteriorate as the discrepancy between harvested organs and the number of patients in need is increasing. Static cold storage is the clinical standard method for preserving a harvested organ but is associated with several drawbacks. Machine perfusion of an organ has been shown to improve preservation quality as well as preservation time over static cold storage. While there are machine perfusion devices clinically available, they are costly and limited to specific organs and preservation solutions. This study presents a versatile oxygenating perfusion system (VOPS) that supplies oxygen and pulsatile perfusion. Materials and Methods: Experiments evaluated the system's performance with a human kidney mimicking hydraulic analog using multiple compressed oxygen supply pressures and aqueous solutions with viscosities ranging from 1 to 6.5 cP, which simulated viscosities of commonly used organ preservation solutions. Results and Conclusions: The VOPS produced mean flow rates ranging from 0.6 to 28.2 mL/min and perfusion pressures from 4.8 to 96.8 mmHg, which successfully achieved the desired perfusion parameters for human kidneys. This work provides evidence that the VOPS described herein has the versatility to perfuse organs using many of the clinically available preservation solutions.
dc.description.departmentMechanical Engineering
dc.description.departmentBiomedical Engineering and Chemical Engineering
dc.identifierdoi: 10.3390/bioengineering10010002
dc.identifier.citationBioengineering 10 (1): 2 (2023)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1584
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectorgan preservation
dc.subjectkidney preservation
dc.subjectmachine perfusion
dc.subjecttransplantation
dc.subjecttissue preservation
dc.subjecttransplantation
dc.subjectstatic cold storage
dc.subjectviscosity
dc.titleEvaluating the Performance of a Nonelectronic, Versatile Oxygenating Perfusion System across Viscosities Representative of Clinical Perfusion Solutions Used for Organ Preservation
dc.typeArticle

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