The Microbiota–Gut–Brain Axis–Heart Shunt Part II: Prosaic Foods and the Brain–Heart Connection in Alzheimer Disease

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dc.contributor.authorObrenovich, Mark
dc.contributor.authorTabrez, Shams
dc.contributor.authorSiddiqui, Bushra
dc.contributor.authorMcCloskey, Benjamin
dc.contributor.authorPerry, George
dc.date.accessioned2021-04-19T15:19:06Z
dc.date.available2021-04-19T15:19:06Z
dc.date.issued2020-03-31
dc.date.updated2021-04-19T15:19:06Z
dc.description.abstractThere is a strong cerebrovascular component to brain aging, Alzheimer disease, and vascular dementia. Foods, common drugs, and the polyphenolic compounds contained in wine modulate health both directly and through the gut microbiota. This observation and novel findings centered on nutrition, biochemistry, and metabolism, as well as the newer insights we gain into the microbiota-gut-brain axis, now lead us to propose a shunt to this classic triad, which involves the heart and cerebrovascular systems. The French paradox and prosaic foods, as they relate to the microbiota-gut-brain axis and neurodegenerative diseases, are discussed in this manuscript, which is the second part of a two-part series of concept papers addressing the notion that the microbiota and host liver metabolism all play roles in brain and heart health.
dc.description.departmentNeuroscience, Developmental and Regenerative Biology
dc.description.departmentChemistry
dc.identifierdoi: 10.3390/microorganisms8040493
dc.identifier.citationMicroorganisms 8 (4): 493 (2020)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/486
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFrench paradox
dc.subjectpolyphenol
dc.subjectcerebrovascular
dc.subjectheart
dc.subjectbrain
dc.subjectmicrobiota-gut-brain axis
dc.subjecttrimethylamine-N-oxide (TMANO/TMAO)
dc.subjectco-metabolism
dc.subjectAlzheimer disease
dc.subjectParkinson’s disease
dc.subjectprosaic foods
dc.subjectred wine
dc.titleThe Microbiota–Gut–Brain Axis–Heart Shunt Part II: Prosaic Foods and the Brain–Heart Connection in Alzheimer Disease
dc.typeArticle

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