Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains

Date
2016-10-21
Authors
Abastabar, Mahdi
Rahimi, Nooshin
Meis, Jacques F.
Aslani, Narges
Khodavaisy, Sadegh
Nabili, Mojtaba
Rezaei-Matehkolaei, Ali
Makimura, Koichi
Badali, Hamid
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract

A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC90 values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml.

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Citation
Abastabar, M., Rahimi, N., Meis, J. F., Aslani, N., Khodavaisy, S., Nabili, M., ... Badali, H. (2016). Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains. Antimicrobial Agents and Chemotherapy, 60(11). doi:10.1128/aac.01193-16
Department
Molecular Microbiology and Immunology