Epidemiology and Antifungal Susceptibilities of Mucoralean Fungi in Clinical Samples from the United States

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dc.contributor.authorBadali, Hamid
dc.contributor.authorCañete-Gibas, Connie
dc.contributor.authorMcCarthy, Dora
dc.contributor.authorPatterson, Hoja
dc.contributor.authorSanders, Carmita
dc.contributor.authorDavid, Marjorie P.
dc.contributor.authorMele, James
dc.contributor.authorFan, Hongxin
dc.contributor.authorWiederhold, Nathan P.
dc.creator.orcidhttps://orcid.org/0000-0002-6010-8414en_US
dc.date.accessioned2023-07-17T18:00:42Z
dc.date.available2023-07-17T18:00:42Z
dc.date.issued2021-08-18
dc.description.abstractThe global incidence of mucormycosis has increased in recent years owing to higher numbers of individuals at risk for these infections. The diagnosis and treatment of this aggressive fungal infection are of clinical concern due to differences in species distribution in different geographic areas and susceptibility profiles between different species that are capable of causing highly aggressive infections. The purpose of this study was to evaluate the epidemiology and susceptibility profiles of Mucorales isolates in the United States over a 52-month period. Species identification was performed by combined phenotypic characteristics and DNA sequence analysis, and antifungal susceptibility testing was performed by CLSI M38 broth microdilution for amphotericin B, isavuconazole, itraconazole, and posaconazole. During this time frame, 854 isolates were included, representing 11 different genera and over 26 species, of which Rhizopus (58.6%) was the predominant genus, followed by Mucor (19.6%). The majority of isolates were cultured from the upper and lower respiratory tracts (55%). Amphotericin B demonstrated the most potent in vitro activity, with geometric mean (GM) MICs of ≤0.25 μg/ml against all genera with the exception of Cunninghamella species (GM MIC of 1.30 μg/ml). In head-to-head comparisons, the most active azole was posaconazole, followed by isavuconazole. Differences in azole and amphotericin B susceptibility patterns were observed between the genera with the greatest variability observed with isavuconazole. Awareness of the epidemiology of Mucorales isolates and differences in antifungal susceptibility patterns in the United States may aide clinicians in choosing antifungal treatment regimens. Further studies are warranted to correlate these findings with clinical outcomes.en_US
dc.description.departmentMolecular Microbiology and Immunologyen_US
dc.description.sponsorshipAstellas Pharma, Inc.en_US
dc.identifier.citationBadali, H., Cañete-Gibas, C., McCarthy, D., Patterson, H., Sanders, C., David, M. P., . . . Wiederhold, N. P. (2021). Epidemiology and Antifungal Susceptibilities of Mucoralean Fungi in Clinical Samples from the United States. Journal of Clinical Microbiology, 59(9), 10.1128/jcm.01230-01221. doi:10.1128/jcm.01230-21en_US
dc.identifier.issn1098-660X
dc.identifier.otherhttps://doi.org/10.1128/JCM.01230-21
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1992
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofseriesJournal of Clinical Microbiology;Vol. 59, No. 9
dc.subjectmucormycosisen_US
dc.subjectmucoralean fungien_US
dc.subjectantifungal susceptibilityen_US
dc.subjectamphotericin Ben_US
dc.subjectposaconazoleen_US
dc.subjectisavuconazoleen_US
dc.subjectRhizopusen_US
dc.subjectMucoren_US
dc.subjectantifungalen_US
dc.subjectMucoralesen_US
dc.subjectsusceptibilityen_US
dc.titleEpidemiology and Antifungal Susceptibilities of Mucoralean Fungi in Clinical Samples from the United Statesen_US
dc.typeArticleen_US

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