3-D biocompatible microneedle arrays with nanoporous surface

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dc.contributorInternational FAIM Conference 24th : 2014 : San Antonio, Texas
dc.contributorUniversity of Texas at San Antonio. Center for Advanced Manufacturing and Lean Systems
dc.contributor.authorChen, Po Chun
dc.contributor.authorHsieh, Sheng Jen
dc.date.accessioned2022-07-11T17:35:47Z
dc.date.available2022-07-11T17:35:47Z
dc.date.issued2014
dc.descriptionPaper presented at the Proceedings of the 24th International Conference on Flexible Automation & Intelligent Manufacturing, held May 20-23, 2014 in San Antonio, Texas, and organized by the Center for Advanced Manufacturing and Lean Systems, University of Texas at San Antonio
dc.descriptionIncludes bibliographical references
dc.descriptionDuring the past few years, developing painless needles or patches to replace traditional hypodermic needles has been investigated. Since micromachining can be used to construct a high density metallic micropillar array, we propose to use a biocompatible metal oxide, such as Al2O3 and TiO2, as an alternative material for fabricating arrays of microneedles. In this study, we fabricated an anodic aluminum oxide (AAO) covered Al micro-indent array using electrochemical and mechanical micromachining. We demonstrate use of a nanoindenter to make pyramidal indentions on Al surface in order to produce a female microneedle array mold. We also performed melting injection to fill AAO template with ultra-high molecular weight polyethylene (UHMWPE) to produce UHMWPE nanotubes. The microneedle array provides a 3-D structure that possesses several hundred times more surface area than a traditional nanotube template. This suggests that a medical-grade polymer microneedle array can potentially be formed for more applications. This 3-D microneedle array device can be used not only for painless injection or extraction, but also for storage, highly sensitive detection, drug delivery, and microelectrodes
dc.description.abstractDuring the past few years, developing painless needles or patches to replace traditional hypodermic needles has been investigated. Since micromachining can be used to construct a high density metallic micropillar array, we propose to use a biocompatible metal oxide, such as Al2O3 and TiO2, as an alternative material for fabricating arrays of microneedles. In this study, we fabricated an anodic aluminum oxide (AAO) covered Al micro-indent array using electrochemical and mechanical micromachining. We demonstrate use of a nanoindenter to make pyramidal indentions on Al surface in order to produce a female microneedle array mold. We also performed melting injection to fill AAO template with ultra-high molecular weight polyethylene (UHMWPE) to produce UHMWPE nanotubes. The microneedle array provides a 3-D structure that possesses several hundred times more surface area than a traditional nanotube template. This suggests that a medical-grade polymer microneedle array can potentially be formed for more applications. This 3-D microneedle array device can be used not only for painless injection or extraction, but also for storage, highly sensitive detection, drug delivery, and microelectrodes.
dc.identifier.otherhttp://dx.doi.org/10.14809/faim.2014.0977
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1039
dc.language.isoen_US
dc.publisherDEStech Publications, Inc.
dc.relation.ispartofseriesProceedings of the 24th International Conference on Flexible Automation & Intelligent Manufacturing
dc.subjectPins and needles--Design and construction
dc.subjectPins and needles--Anodic oxidation
dc.subjectMicromachining
dc.subjectMicroinjections
dc.title3-D biocompatible microneedle arrays with nanoporous surface
dc.typeArticle

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