Carlos Alvarez College of Business
Permanent URI for this communityhttps://hdl.handle.net/20.500.12588/250
Nationally ranked and internationally recognized, the UTSA Carlos Alvarez College of Business (COB) offers a comprehensive curriculum that transforms business students into business professionals. The college offers traditional degrees in areas such as accounting, finance and marketing as well as specialized programming in cyber security, data analytics and real estate finance and development. The college is accredited by AACSB International, the Association to Advance Collegiate Schools of Business, placing it among the top 5% of business schools nationwide.
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Browsing Carlos Alvarez College of Business by Author "Bowirrat, Abdalla"
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Item Genetic Addiction Risk and Psychological Profiling Analyses for "Preaddiction" Severity Index(2022-10-27) Blum, Kenneth; Han, David; Bowirrat, Abdalla; Downs, Bernard William; Bagchi, Debasis; Thanos, Panayotis K.; Baron, David; Braverman, Eric R.; Dennen, Catherine A.; Gupta, Ashim; Elman, Igor; Badgaiyan, Rajendra D.; Llanos-Gomez, Luis; Khalsa, Jag; Barh, Debmalya; McLaughlin, Thomas; Gold, Mark S.Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including genome-wide association studies (GWAS). To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of reward deficiency syndrome (RDS), Blum's group developed the genetic addiction risk severity (GARS) test, consisting of ten genes and eleven associated risk alleles. In order to statistically validate the selection of these risk alleles measured by GARS, we applied strict analysis to studies that investigated the association of each polymorphism with AUD or AUD-related conditions, including pain and even bariatric surgery, as a predictor of severe vulnerability to unwanted addictive behaviors, published since 1990 until now. This analysis calculated the Hardy–Weinberg Equilibrium of each polymorphism in cases and controls. Pearson's χ2 test or Fisher's exact test was applied to compare the gender, genotype, and allele distribution if available. The statistical analyses found the OR, 95% CI for OR, and the post risk for 8% estimation of the population's alcoholism prevalence revealed a significant detection. Prior to these results, the United States and European patents on a ten gene panel and eleven risk alleles have been issued. In the face of the new construct of the "preaddiction" model, similar to "prediabetes", the genetic addiction risk analysis might provide one solution missing in the treatment and prevention of the neurological disorder known as RDS.Item Positive Clinical Outcomes for Severe Reported Pain Using Robust Non-Addictive Home Electrotherapy—A Case-Series(2023-02-15) Bajaj, Anish; Han, David; Elman, Igor; Thanos, Panayotis K.; Dennen, Catherine A.; Badgaiyan, Rajendra D.; Bowirrat, Abdalla; Barh, Debmalya; Blum, KennethThe North American opioid epidemic has resulted in over 800,000 related premature overdose fatalities since 2000, with the United States leading the world in highest opioid deaths per capita. Despite increased federal funding in recent years, intended to address this crisis, opioid overdose mortality has continued to increase. Legally prescribed opioids also chronically induce a problematic reduction in affect. While an ideal analgesic has yet to be developed, some effective multimodal non-opioid pharmacological regimens for acute pain management are being more widely utilized. Some investigators have suggested that a safer and more scientifically sound approach might be to induce "dopamine homeostasis" through non-pharmacological approaches, since opioid use even for acute pain of short duration is now being strongly questioned. There is also increasing evidence suggesting that some more robust forms of electrotherapy could be applied as an effective adjunct to avoid the problems associated with opioids. This 4-patient case-series presents such an approach to treatment of severe pain. All 4 of these chiropractic treatment cases involved a component of knee osteoarthritis, in addition to other reported areas of pain. Each patient engaged in a home recovery strategy using H-Wave(R) device stimulation (HWDS) to address residual extremity issues following treatment of spinal subluxation and other standard treatments. A simple statistical analysis was conducted to determine the change in pain scores (Visual Analogue Scale) of pre and post electrotherapy treatments, resulting in significant reductions in self-reported pain (p-value = 0.0002). Three of the four patients continued using the home therapy device long-term as determined by a post-analysis questionnaire. This small case-series demonstrated notably positive outcomes, suggesting consideration of home use of HWDS for safe, non-pharmacological and non-addictive treatment of severe pain.Item Statistical Validation of Risk Alleles in Genetic Addiction Risk Severity (GARS) Test: Early Identification of Risk for Alcohol Use Disorder (AUD) in 74,566 Case–Control Subjects(2022-08-26) Blum, Kenneth; Han, David; Gupta, Ashim; Baron, David; Braverman, Eric R.; Dennen, Catherine A.; Kazmi, Shan; Llanos-Gomez, Luis; Badgaiyan, Rajendra D.; Elman, Igor; Thanos, Panayotis K.; Downs, Bill W.; Bagchi, Debasis; Gondre-Lewis, Marjorie C.; Gold, Mark S.; Bowirrat, AbdallaSince 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including GWAS. To develop an accurate test to help identify those at risk for at least Alcohol Use Disorder (AUD), Blum’s group developed the Genetic Addiction Risk Severity (GARS) test, consisting of ten genes and eleven associated risk alleles. In order to statistically validate the selection of these risk alleles measured by GARS, we applied strict analysis to studies that investigated the association of each polymorphism with AUD or AUD-related conditions published from 1990 until 2021. This analysis calculated the Hardy–Weinberg Equilibrium of each polymorphism in cases and controls. If available, the Pearson’s χ2 test or Fisher’s exact test was applied to comparisons of the gender, genotype, and allele distribution. The statistical analyses found the OR, 95% CI for OR, and a post-risk for 8% estimation of the population’s alcoholism prevalence revealed a significant detection. The OR results showed significance for DRD2, DRD3, DRD4, DAT1, COMT, OPRM1, and 5HTT at 5%. While most of the research related to GARS is derived from our laboratory, we are encouraging more independent research to confirm our findings.