Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone
| dc.contributor.author | Hayden, Celine A. | |
| dc.contributor.author | Landrock, Danilo | |
| dc.contributor.author | Hung, Chiung-Yu | |
| dc.contributor.author | Ostroff, Gary | |
| dc.contributor.author | Fake, Gina M. | |
| dc.contributor.author | Walker, John H. | |
| dc.contributor.author | Kier, Ann | |
| dc.contributor.author | Howard, John A. | |
| dc.date.accessioned | 2021-04-19T15:18:20Z | |
| dc.date.available | 2021-04-19T15:18:20Z | |
| dc.date.issued | 2020-01-21 | |
| dc.date.updated | 2021-04-19T15:18:20Z | |
| dc.description.abstract | Infectious diseases continue to be a significant cause of morbidity and mortality, and although efficacious vaccines are available for many diseases, some parenteral vaccines elicit little or no mucosal antibodies which can be a significant problem since mucosal tissue is the point of entry for 90% of pathogens. In order to provide protection for both serum and mucosal areas, we have tested a combinatorial approach of both parenteral and oral administration of antigens for diseases caused by a viral pathogen, Hepatitis B, and a fungal pathogen, Coccidioides. We demonstrate that co-administration by the parenteral and oral routes is a useful tool to increase the overall immune response. This can include achieving an immune response in tissues that are not elicited when using only one route of administration, providing a higher level of response that can lead to fewer required doses or possibly providing a better response for individuals that are considered poor or non-responders. | |
| dc.description.department | Molecular Microbiology and Immunology | |
| dc.identifier | doi: 10.3390/vaccines8010037 | |
| dc.identifier.citation | Vaccines 8 (1): 37 (2020) | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12588/475 | |
| dc.rights | Attribution 4.0 United States | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | subunit vaccine | |
| dc.subject | mucosal | |
| dc.subject | maize oral vaccine | |
| dc.subject | plant vaccine | |
| dc.subject | bioencapsulation | |
| dc.subject | immunogenicity | |
| dc.subject | supercritical fluid extraction | |
| dc.title | Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone | |
| dc.type | Article |