Assessment of Plasmonic Photothermal Therapy Through a Fiberoptic Microneedle Device for Pancreatic Cancer Treatment

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dc.contributor.advisorHood, Lyle
dc.contributor.authorAkhter, Forhad
dc.contributor.committeeMemberMayer, Kathryn
dc.contributor.committeeMemberFeng, Yusheng
dc.contributor.committeeMemberFinol, Ender
dc.contributor.committeeMemberRestrepo, David
dc.contributor.committeeMemberDe Lorenzo, Robert
dc.creator.orcidhttps://orcid.org/0000-0002-5030-1632
dc.date.accessioned2024-01-25T21:50:02Z
dc.date.available2025-05-25
dc.date.issued2021
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractCurrent clinical approaches for treating pancreatic cancer have been demonstrated as ineffective at improving midterm survival (<10%). Plasmonic photothermal therapy (PPTT) has been rarely explored as a treatment method for pancreatic cancer. Clinically used endoscopic ultrasound (EUS) can be coupled with a thin capillary fiberoptic for transferring light and gold nanoparticles to the targeted tissue volume for selective photothermal heating. PPTT requires knowledge of tissue specific thermal and optical properties. Literature review revealed a gap in such properties for pancreas tissue. To assess the proposed treatment, and to bridge the gap in the literature, a fiberoptic microneedle device (FMD) has been fabricated utilizing a silica based light guiding capillary through the fusion splice method. The optical, fluid, and mechanical characterization tests of FMD showed the high light coupling efficiency (~75%), maximum internal fluid pressure (~3MPa), and ability to penetrate a soft tissue phantom without tip buckling. Clinical EUS was used to investigate the benchtop optical visualization of FMD. Ex vivo porcine pancreas tissue was utilized to evaluate the thermal conductivity, light attenuation coefficient, absorption coefficient, and reduced scattering coefficient at 808 and 1064 nm laser wavelengths. Finally, the photothermal heating of ex vivo tissue was characterized by developing a computational model and implementing FMD for co-delivering variable light intensities and gold nanorod concentrations. These tests showed the effectiveness of PPTT in selective photothermal heating of tissue through manipulation of GNR concentration and light wavelengths.
dc.description.departmentMechanical Engineering
dc.format.extent179 pages
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12588/2396
dc.languageen
dc.subjectFiberoptic
dc.subjectGold Nanoparticles
dc.subjectMicroneedle
dc.subjectPancreatic Cancer
dc.subjectPhotothermal Therapy
dc.subjectPlasmonic Heating
dc.subject.classificationMechanical engineering
dc.titleAssessment of Plasmonic Photothermal Therapy Through a Fiberoptic Microneedle Device for Pancreatic Cancer Treatment
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
local.embargo.lift2025-05-25
local.embargo.terms2025-05-25
thesis.degree.departmentMechanical Engineering
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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