Attempted Synthesis of Casbene by Intramolecular Cyclopropanation

Date
2002-11-14
Authors
Doyle, Michael
Yan, Ming
Journal Title
Journal ISSN
Volume Title
Publisher
ARKAT USA
Abstract

The antifungal diterpene casbene has been prepared in low yield by intramolecular cyclopropanation of the vinyldiazomethane reactant formed from geranylgeraniol. Careful analysis of the reaction mixture revealed relatively unselective addition catalyzed by dirhodium(II) and copper(I) catalysts.

Description
Keywords
Dirhodium(II) catalysis, vinyldiazomethane, copper(I) catalysis, diterpene, macro-cyclization
Citation
https://doi.org/10.3998/ark.5550190.0003.818
Department
Chemistry