Investigation of data processing pipeline for high supersequence based methylation (Methyl-Seq)

Date
2012
Authors
Macintyre, Melissa Lynn
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Abstract

The purpose of this thesis is to understand and implement a pipeline for processing high supersequence DNA data. This research project investigates the technology behind the most widely used platforms in the industry. It also investigates the interpretation of standard data formats. Research was conducted to investigate alignment software and key algorithms used to speed up the alignment process. Finally a pipeline is put in place so that a raw data file can be aligned and visualized for methylation data. The software is available at the computational biology initiative so that in the future it will be accessible through the University of Texas at San Antonio.

Description
This item is available only to currently enrolled UTSA students, faculty or staff.
Keywords
Bowtie2, BWA, Methylation, Pipeline, Sequencing
Citation
Department
Electrical and Computer Engineering