An Innovative Polymeric Platform for Controlled and Localized Drug Delivery

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dc.contributor.authorElbjorn, Monica
dc.contributor.authorProvencio, Jacob
dc.contributor.authorPhillips, Paige
dc.contributor.authorSainz, Javier
dc.contributor.authorHarrison, Noah
dc.contributor.authorDi Rocco, David
dc.contributor.authorJaramillo, Ada
dc.contributor.authorJain, Priya
dc.contributor.authorLozano, Alejandro
dc.contributor.authorHood, R. Lyle
dc.date.accessioned2023-07-28T12:21:43Z
dc.date.available2023-07-28T12:21:43Z
dc.date.issued2023-06-23
dc.date.updated2023-07-28T12:21:45Z
dc.description.abstractPrecision medicine aims to optimize pharmacological treatments by considering patients' genetic, phenotypic, and environmental factors, enabling dosages personalized to the individual. To address challenges associated with oral and injectable administration approaches, implantable drug delivery systems have been developed. These systems overcome issues like patient adherence, bioavailability, and first-pass metabolism. Utilizing new combinations of biodegradable polymers, the proposed solution, a Polymeric Controlled Release System (PCRS), allows minimally invasive placement and controlled drug administration over several weeks. This study's objective was to show that the PCRS exhibits a linear biphasic controlled release profile, which would indicate potential as an effective treatment vehicle for cervical malignancies. An injection mold technique was developed for batch manufacturing of devices, and in vitro experiments demonstrated that the device's geometry and surface area could be varied to achieve various drug release profiles. This study's results motivate additional development of the PCRS to treat cervical cancer, as well as other malignancies, such as lung, testicular, and ovarian cancers.
dc.description.departmentMechanical Engineering
dc.identifierdoi: 10.3390/pharmaceutics15071795
dc.identifier.citationPharmaceutics 15 (7): 1795 (2023)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/2005
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectpolymeric drug delivery
dc.subjecttargeted drug delivery system
dc.subjectpolycaprolactone
dc.subjectpoly-lactic acid
dc.subjectrhodamine B
dc.subjectpolymer casting
dc.subjectcervical cancer
dc.titleAn Innovative Polymeric Platform for Controlled and Localized Drug Delivery
dc.typeArticle

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