In Vitro Antifungal Susceptibility Profile of Miltefosine against a Collection of Azole and Echinocandins Resistant Fusarium Strains

Date
2022-07-04
Authors
Nosratabadi, Mohsen
Akhtari, Javad
Faeli, Leila
Haghani, Iman
Aghili, Seyed Reza
Shokohi, Tahereh
Hedayati, Mohammad Taghi
Zarrinfar, Hossein
Mohammadi, Rasoul
Najafzadeh, Mohammad Javad
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Abstract

Fusarium species are filamentous fungi that cause a variety of infections in humans. Because they are commonly resistant to many antifungal drugs currently available in clinical settings, research into alternative targets in fungal cells and therapeutic approaches is required. The antifungal activity of miltefosine and four comparators, amphotericin B, voriconazole, itraconazole, and caspofungin, were tested in vitro against a collection of susceptible and resistant clinical (n = 68) and environmental (n = 42) Fusarium isolates. Amphotericin B (0.8 µg/mL) had the lowest geometric mean (GM) MICs/MECs values followed by miltefosine (1.44 µg/mL), voriconazole (2.15 µg/mL), caspofungin (7.23 µg/mL), and itraconazole (14.19 µg/mL). Miltefosine was the most effective agent against Fusarium isolates after amphotericin B indicating that miltefosine has the potential to be studied as a novel treatment for Fusarium infections.

Description
Keywords
miltefosine, Fusarium species, antifungal drugs, resistance
Citation
Journal of Fungi 8 (7): 709 (2022)
Department
Molecular Microbiology and Immunology