In Vitro Antifungal Susceptibility Profile of Miltefosine against a Collection of Azole and Echinocandins Resistant Fusarium Strains

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dc.contributor.authorNosratabadi, Mohsen
dc.contributor.authorAkhtari, Javad
dc.contributor.authorFaeli, Leila
dc.contributor.authorHaghani, Iman
dc.contributor.authorAghili, Seyed Reza
dc.contributor.authorShokohi, Tahereh
dc.contributor.authorHedayati, Mohammad Taghi
dc.contributor.authorZarrinfar, Hossein
dc.contributor.authorMohammadi, Rasoul
dc.contributor.authorNajafzadeh, Mohammad Javad
dc.contributor.authorKhodavaisy, Sadegh
dc.contributor.authorAl-Harrasi, Ahmed
dc.contributor.authorJavan-Nikkhah, Mohammad
dc.contributor.authorKachuei, Reza
dc.contributor.authorSalimi, Maryam
dc.contributor.authorFattahi, Mahsa
dc.contributor.authorBadali, Hamid
dc.contributor.authorAl Hatmi, Abdullah M. S.
dc.contributor.authorAbastabar, Mahdi
dc.date.accessioned2022-07-25T16:32:44Z
dc.date.available2022-07-25T16:32:44Z
dc.date.issued2022-07-04
dc.date.updated2022-07-25T16:32:46Z
dc.description.abstractFusarium species are filamentous fungi that cause a variety of infections in humans. Because they are commonly resistant to many antifungal drugs currently available in clinical settings, research into alternative targets in fungal cells and therapeutic approaches is required. The antifungal activity of miltefosine and four comparators, amphotericin B, voriconazole, itraconazole, and caspofungin, were tested in vitro against a collection of susceptible and resistant clinical (n = 68) and environmental (n = 42) Fusarium isolates. Amphotericin B (0.8 µg/mL) had the lowest geometric mean (GM) MICs/MECs values followed by miltefosine (1.44 µg/mL), voriconazole (2.15 µg/mL), caspofungin (7.23 µg/mL), and itraconazole (14.19 µg/mL). Miltefosine was the most effective agent against Fusarium isolates after amphotericin B indicating that miltefosine has the potential to be studied as a novel treatment for Fusarium infections.
dc.description.departmentMolecular Microbiology and Immunology
dc.identifierdoi: 10.3390/jof8070709
dc.identifier.citationJournal of Fungi 8 (7): 709 (2022)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1066
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmiltefosine
dc.subjectFusarium species
dc.subjectantifungal drugs
dc.subjectresistance
dc.titleIn Vitro Antifungal Susceptibility Profile of Miltefosine against a Collection of Azole and Echinocandins Resistant Fusarium Strains
dc.typeArticle

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