Natural Product Co-Metabolism and the Microbiota–Gut–Brain Axis in Age-Related Diseases

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dc.contributor.authorObrenovich, Mark
dc.contributor.authorSingh, Sandeep Kumar
dc.contributor.authorLi, Yi
dc.contributor.authorPerry, George
dc.contributor.authorSiddiqui, Bushra
dc.contributor.authorHaq, Waqas
dc.contributor.authorReddy, V. Prakash
dc.date.accessioned2023-01-20T14:23:22Z
dc.date.available2023-01-20T14:23:22Z
dc.date.issued2022-12-23
dc.date.updated2023-01-20T14:23:23Z
dc.description.abstractComplementary alternative medicine approaches are growing treatments of diseases to standard medicine practice. Many of these concepts are being adopted into standard practice and orthomolecular medicine. Age-related diseases, in particular neurodegenerative disorders, are particularly difficult to treat and a cure is likely a distant expectation for many of them. Shifting attention from pharmaceuticals to phytoceuticals and "bugs as drugs" represents a paradigm shift and novel approaches to intervention and management of age-related diseases and downstream effects of aging. Although they have their own unique pathologies, a growing body of evidence suggests Alzheimer's disease (AD) and vascular dementia (VaD) share common pathology and features. Moreover, normal metabolic processes contribute to detrimental aging and age-related diseases such as AD. Recognizing the role that the cerebral and cardiovascular pathways play in AD and age-related diseases represents a common denominator in their pathobiology. Understanding how prosaic foods and medications are co-metabolized with the gut microbiota (GMB) would advance personalized medicine and represents a paradigm shift in our view of human physiology and biochemistry. Extending that advance to include a new physiology for the advanced age-related diseases would provide new treatment targets for mild cognitive impairment, dementia, and neurodegeneration and may speed up medical advancements for these particularly devastating and debilitating diseases. Here, we explore selected foods and their derivatives and suggest new dementia treatment approaches for age-related diseases that focus on reexamining the role of the GMB.
dc.description.departmentNeuroscience, Developmental and Regenerative Biology
dc.description.departmentChemistry
dc.identifierdoi: 10.3390/life13010041
dc.identifier.citationLife 13 (1): 41 (2023)
dc.identifier.urihttps://hdl.handle.net/20.500.12588/1589
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectnatural products
dc.subjectGinkgo biloba
dc.subjectvascular dementia
dc.subjectAlzheimer’s disease
dc.subjectmicrobiota
dc.subjectmicrobiome
dc.subjectmicrobiota-gut-brain axis
dc.subjectmetabolic interactome
dc.subjectblood-brain barrier
dc.subjectaging
dc.titleNatural Product Co-Metabolism and the Microbiota–Gut–Brain Axis in Age-Related Diseases
dc.typeArticle

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