The Role of Trabeculae Carneae on the Left Ventricular Diastolic and Systolic Functions

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dc.contributor.advisorHan, Hai-Chao
dc.contributor.authorFatemi Far, Fatemeh
dc.contributor.committeeMemberFeldman, Marc
dc.contributor.committeeMemberFinol, Ender
dc.contributor.committeeMemberZeng, Xiaowei
dc.date.accessioned2024-02-09T21:11:53Z
dc.date.available2018-11-15
dc.date.available2024-02-09T21:11:53Z
dc.date.issued2018
dc.descriptionThis item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.
dc.description.abstractReduced left ventricular (LV) compliance is the hallmark of heart failure with preserved ejection fraction (HFpEF), which is the leading cause of all heart failure hospitalizations. LV stiffness is related to the thickness of the myocardium and the extent of fibrosis as LV hypertrophy develops. LV hypertrophy is also associated with the thickening and fibrosis of the trabeculae carneae. Our recent studies suggested that trabeculae carneae have a noticeable effect on the overall stiffness of LV, and severing free-running trabeculae carneae may help increase the compliance of LV in HFpEF patients. Therefore, it is of clinical interest to better understand the microstructural and material properties and mechanical role of trabeculae carneae in human LV. Mechanical properties and microstructural characteristics of trabeculae carneae were determined through conducting ex-vivo experiments on explanted human hearts. Knowing these mechanical properties enabled us to develop accurate computational models of LV. MR images were acquired from an explanted human heart and patient-specific model of LV with detailed anatomy of trabeculae carneae was generated. Virtual experiments of severing free-running trabeculae carneae were performed using finite element analysis. The changes in stiffness, diastolic function and systolic function of LV were evaluated. The results from this study will clarify the role of trabeculae carneae in LV function and set a base for developing new treatment for HFpEF patients.
dc.description.departmentMechanical Engineering
dc.format.extent146 pages
dc.format.mimetypeapplication/pdf
dc.identifier.isbn9780355957891
dc.identifier.urihttps://hdl.handle.net/20.500.12588/3569
dc.languageen
dc.subjectartery
dc.subjectdiastolic
dc.subjectmyocardium
dc.subjectsystolic
dc.subjectTrabeculae
dc.subjectvein
dc.subject.classificationBioengineering
dc.subject.classificationMechanical engineering
dc.titleThe Role of Trabeculae Carneae on the Left Ventricular Diastolic and Systolic Functions
dc.typeThesis
dc.type.dcmiText
dcterms.accessRightspq_closed
thesis.degree.departmentMechanical Engineering
thesis.degree.grantorUniversity of Texas at San Antonio
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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